據(jù)SSI呼吸代謝技術(shù)2022年1月20日最新參考信息，鎮(zhèn)靜劑右美托咪定可能有助于治療重癥監(jiān)護(hù)中的COVID19患者——但它如何影響呼吸和血壓？

右美托咪定可維持一定程度的鎮(zhèn)靜狀態(tài)，有利于降低機(jī)體的氧耗率，改善氧合。來自日本牙科大學(xué)的科學(xué)家采用Foxbox呼吸代謝技術(shù)構(gòu)建了如下圖所示的鎮(zhèn)靜大鼠呼吸與血壓測定裝置，進(jìn)行右美托咪定對自主呼吸成年大鼠心肺調(diào)節(jié)影響研究。

相關(guān)研究成果見2022年1月14日PLOS ONE在線論文“Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats"。

參考資料

1.Zhou L, Gu W, Kui F, et al. The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer. Food & Nutrition Research. 2021 ;65. DOI: 10.29219/fnr.v65.7526. 

2.Wearing, O.H., Ivy, C.M., Gutiérrez-Pinto, N. et al. The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice. BMC Biol 19, 128 (2021).

3.Catherine M.Ivy,Haley Prest,Claire M.West,and Graham R.Scott. Distinct Mechanisms Underlie Developmental Plasticity and Adult Acclimation of Thermogenic Capacity in High-Altitude Deer Mice. Front Physiol. 2021;12:718163. 11.doi:10.3389/fphys.2021.718163.